How Long Does Oxycodone Stay In Your System: Things You Should Know

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Oxycodone is a derivative of the poppy plant. It works to relieve pain by binding to the opioid receptor which blocks it. It affects the pleasure center of the brain and is a highly addictive medication. It is classified as a federally controlled substance. Oxycodone changes the way the nervous system and the brain respond to pain. It also depresses the central nervous system, including your heart rate and breathing, as well as other important functions. Withdrawal symptoms will be felt if you abruptly discontinue use. If you have ever asked how long does oxycodone stay in your system, you will find information in this article which will tell you all about it.

What Are The Chemical Components In Oxycodone?

Oxycodone is a morphine-like opioid alkaloid that is semi-synthetic. It binds to the receptors in the nervous system. It may be administered intranasally, by suppository, injection, liquid solution, capsule, and tablet. Some of the brand names include:

  • Xtampza
  • Targin
  • Proladine
  • Endone
  • Oxynorm
  • Roxicodone
  • Endodan
  • Percodan
  • Endocet
  • Roxicet
  • Percocet
  • OxyContin
  • Tylox

This opioid-based substance stimulates the production of beta-endorphins. This is how it relieves your pain. The analgesic effect if offers repress the production of GABA. When GABA is released, it inhibits dopamine production. Oxycodone increases dopamine in the brain, which creates feelings of euphoria and happiness. This is why people who take this medication can become dependent on it and sometimes addicted.

Time It Takes To Feel Effects

The time it takes to feel the effects of oxycodone varies by the individual. Usually, you will be given a lower dose to start with, and then it will be increased as you begin to feel relief. People who have taken opioids may need a higher dose to get the desired results. Oxycodone is taken orally with food, and the effects should be felt about 20 to 30 minutes later. It will reach its peak efficiency in 1 to 2 hours. Extended and controlled-release versions can take 3 to 4 hours to reach optimum efficacy.

Over time, tolerance can build. This can present itself as the medication taking longer to work, or there will not be as strong of an effect. Your doctor may increase your prescription or switch to another medication if this happens. Never increase your dosage on your own.

Time It Takes For Effects To Wear Off

The time it takes for oxycodone to wear off can be measured by its half-life. Immediate-release pills will take on average 3.2 hours. Controlled or extended-release pills will take an average 4.5 to 5.6 hours. Oxycodone will be out of the bloodstream in 24 hours, but will still be detected in the hair, urine, blood, and saliva for a longer period of time.

Detection time:

  • Hair - up to 90 days after last dose
  • Urine - 3 to 4 days after last dose
  • Saliva - 1 to 4 days after last dose
  • Blood - up to 24 hours

Detection testing can be done by forensic, medical, and employment drug abuse screening. These times are estimates of the time it takes to metabolize oxycodone. If you have taken, or currently are taking it, and are having a drug test, you should disclose this to the laboratory, so they can accurately interpret your results.

How Long Effects Last

There are many factors that go into knowing how long the effects will last that include taking into account:


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There is a danger of an overdose with those who drink alcohol with oxycodone. It will also take longer to clear.

Kidney Function

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For those with kidney issues, increase the half-life by one hour.

Liver Function


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The half-life of those with liver dysfunction is 2.3 hours. It will take longer for oxycodone to clear.


Females have a 25% higher concentration than males.


For those over 65, blood concentrations appeared to be 15% higher than in younger adult patients. It may take longer for an older patient for the drug to clear their system.

How long does oxycodone stay in your system may depend on these factors as well:

  • Ethnicity
  • Weight
  • Height
  • Body fat percentage
  • Body mass index
  • Presence of food in the GI tract
  • Dosage took
  • Duration of consumption
  • Presence of other opioid drugs

Is The Amount Of Time Oxycodone Stays In Your System Affected By Other Drug Use?

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Drugs that inhibit CYP3A4, a pathway in the body, make it more difficult to break down oxycodone. The following medications are known to result in serious problems that could include respiratory depression:

  • Protease inhibitors
  • Azole antifungal agents like ketoconazole
  • Macrolide antibiotics like erythromycin

How Long Does Oxycodone Stay In Your System?

Oxycodone is used to treat moderate to severe pain. It is an opioid that may be prescribed for those who have had surgery, trauma, or injury. It is also used for pain related to cancer and other severe pain. There are immediate release and controlled or extended release versions. There are also medications that contain oxycodone.

Immediate Release Brands

  • Oxy IR
  • Roxybond
  • Roxycodone
  • Oxaydo

Controlled Brands

  • Xtampza ER
  • OxyContin CR

Combination Medications That Include Oxycodone

  • Oxycodone with acetaminophen (Percocet)
  • Oxycodone with acetaminophen (Xartemis XR)
  • Oxycodone with aspirin (generic)
  • Oxycodone with ibuprofen (generic)

Withdrawal Symptoms

Never abruptly stop taking oxycodone; consult your doctor on how to discontinue your medication. When the body becomes dependent on a drug, you will develop withdrawal symptoms. If you find you are experiencing withdrawal symptoms, it doesn't mean that you are addicted. Drug dependence happens when the body is used to the drug in your bloodstream and when you stop taking it, your symptoms can include:

  • Rapid heartbeat
  • Rapid breathing
  • Sweating
  • Vomiting
  • Joint aches
  • Muscle cramps
  • Yawning
  • Runny nose
  • Watery eyes
  • Restlessness

It may take several weeks for your system to become dependent. Your doctor may gradually reduce your dosage, this is known as tapering, to prevent withdrawal symptoms. You will also be monitored to ensure you don't have withdrawal symptoms. If you find you are having withdrawal symptoms, they can be from mild to moderate or severe. Your symptoms should improve within 72 hours and then decrease over the period of a week. Contact your doctor if you need assistance.

Risk Of Addiction

Oxycodone may become habit-forming; it's important to only take what you are prescribed. You may especially be at risk if you have family members who have alcohol use disorders, regardless if they have never used prescription or illegal drugs. If you have a family history of this type of addiction, make sure to let your healthcare provider know, and be careful to only take as directed.

Treatment For Addiction

If you are wondering how long does oxycodone stay in your system, you may want to discuss this with a medical professional. If it has been suggested that you look into addiction assistance, clinical detox is medically supervised with around the clock care. It can take several days, and you will have a follow-up for at least 30 days to monitor how long oxycodone stays in your system. When intensive care is required, the patient may need to stay in a facility for several weeks while they participate in support groups, counseling, and behavioral therapy. It's important to answer how long does oxycodone stay in your system and learn how to cope. Outpatient therapy is recommended for those who have completed an inpatient program or have other responsibilities.

Knowing how long oxycodone stays in your system is important because of interactions with other drugs and alcohol. If you take more medication before the drug has worn off, you could risk an overdose. Never crush or cut an extended-release tablet or capsule, as you will get the entire dose at once instead of over time as it was intended.

There is no need to face addiction alone; finding the answer to how long does oxycodone stay in your system and finding the right treatment plan will help. Speak to your doctor about a program that may be right for you.


If you have been taking oxycodone, you may wonder how long does oxycodone stay in your system. It's very important to understand the effects it will have on your body and the potential risks there are in taking it. As it affects the pleasure center of the brain, there is the risk of addiction and abuse. This is a powerful opioid used for pain relief. It should be monitored closely by your doctor and cessation should be done slowly and under the advice of your physician. There are a number of factors that should be taken into consideration when taking this medication to ensure there are no serious side effects. Never drink alcohol when taking oxycodone; don't take other street drugs with it as this may result in serious side effects that include breathing issues. Never take more than you are prescribed, as it could result in an overdose. Seek emergency medical care immediately if you experience:

  • Vomiting
  • Weak or limp muscles
  • Constricted pupils
  • Extreme sleepiness
  • Coma or loss of consciousness
  • Clammy, cold skin
  • Stopped or slowed breathing
  • Difficulty breathing

This drug is sometimes abused recreationally. Opioids have been associated with overdose and addiction. The American Society of Addiction Medicine reported that more than 20,000 people died in 2015 from opioid prescription-related overdoses in the US. Take only as prescribed and contact your doctor with questions.

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